Consulting Services.
Engineering expertise for complex bioprocess challenges.

When a design, optimization or scale-up decision is too important to guess, our engineers model your reactor and give you numbers to decide on.

Challenge

Some reactor questions need more than a software license.

Industrial bioprocess projects usually face several of these at once.

  • Flow that changes with scale
  • Cells that respond to their environment in complex ways
  • Little room for experiments
  • Tight timelines
  • Regulatory pressure

In a critical project phase, that combination is hard to handle with software alone.

Our engineers know reactor modeling and have worked on industrial processes, so they can work through high-stakes decisions together with your team.

SimVantage engineer working with a laptop at a lab-scale bioreactor

Focus Areas

Consulting Focus Areas

01

Process Design

  • Checking reactor options early, before equipment is ordered
  • Setting the operating parameters
  • Design choices that still hold at the next scale
  • Process setup backed by simulation

02

Reactor Optimization

  • How fast and how evenly the reactor mixes
  • Energy use and where to reduce it
  • Oxygen and mass transfer
  • Finding the flow problems that limit the process

03

Scale-Up Strategy

  • Finding risks that only show up at larger scale
  • Planning the transfer step by step
  • Evaluating operating conditions with SmartScaler
  • Dealing with those risks before anything changes in the plant

04

Troubleshooting & Root Cause Analysis

  • Finding out why a process behaves unexpectedly
  • Using the model to see which parameters matter
  • Testing possible causes one at a time
  • Support directly in production

05

Experimental Strategy

  • Cutting validation runs that add little
  • Finding out which factors are worth testing
  • Designing experiments around the question you need answered

Approach

Five steps from question to quantified answer.

We run every consulting project the same way.

  1. Problem Definition and Boundary ConditionsTogether we pin down what has to be decided and which limits apply.
  2. Data Integration and ModelingWe set up the models with your process data, so they describe your reactor as it actually runs.
  3. Structured Scenario AnalysisWe compare the options under the same assumptions, so any difference comes from the options themselves.
  4. Quantified Decision SupportYou get numbers for each option, and we tell you where those numbers stop being reliable.
  5. Implementation GuidanceWe stay with you until the change is running on your equipment.

Your engineers and developers are involved throughout, which keeps the results tied to your actual process.

Tools

  • SimVantage Bolt for detailed CFD of your reactor
  • SmartScaler for scale-up questions
  • Custom models when the standard tools do not fit the question

Most projects use more than one of these, depending on the question.

Consulting project outline: kick-off translating your goal into a simulation challenge, analysis of geometry and operating conditions, optimization through validated simulations, and results with recommendations and a summary report

Results

Impact of Our Consulting Projects

30% Shorter mixing time in a 160 m³ production reactor
20% Lower energy demand
€1.3 M Saved on experiments

Use Cases

Typical Reasons to Involve Our Team

  • You are planning an industrial scale-up
  • A process behaves differently at large scale than you expected
  • You are designing a new reactor configuration
  • You want to know which experiments are worth running
  • A reactor uses too much energy or mixes poorly

The earlier we are involved, the fewer surprises reach production scale, where every change costs the most.

Facing a hard reactor question? Discuss it with our team.

Tell us about your reactor and the decision ahead, whether you want more out of an existing vessel or are planning an industrial scale-up. Our models have been validated in production reactors.