See what's happening inside your reactor

Our bioreactor simulation tool will provide you with unique insights.  A high-performance, cloud based simulation tool tailored for gassed and stirred bioreactors. Easy to use for everyone.

Pharmaceutical & Chemical Companies

Lower your scale-up costs

Computational fluid dynamics can reduce the number of tests from 10–15 to 2–3, which typically cost € 40.000 to 80.000 per run [Delvigne et al. 2017].
You can realize those cost savings without the need of expensive simulation experts or computer hardware.

Regulatory affairs

Validate your operating range and reactor design

Due to the cloud computing approach parallel simulations covering entire geometrical or operational parameter ranges can be started easily.  The most recent computer hardware is at your disposal, secured by the Kaleidosim framework to protect your company secrets.

Production

Troubleshoot faster and get a deeper process understanding

Due to the use of the latest generation of graphic cards the simulation results are usually available on the same day to support you in the search for root causes. The simulation results give you a deep insight in the processes inside your reactor.

Equipment manufacturers

Let your customers simulate

Differentiate yourself from your competitors. As an equipment manufacturer, we can provide a simulation portal with your corporate branding. Customers can choose from your reactor portfolio and run their individual tests. You can use the access to the portal as a unique selling proposition for your reactors.

Production

Do virtual process transfers

Compare the conditions your microorganisms experience virtually. Optimize operating conditions before the first batch is produced.

Applications

Usable for

  • mAb, protein and plasmid DNA production
  • Cultivation of mammalian cell lines, insect cells, and stem cells
  • Fermentation of microorganisms (like bacteria, yeasts, and fungi), plant cells and algae
  • Compound mixing and storage hold
  • Vaccine production

 

Test

  • Protein refolding
  • Single use bioreactors
  • Perfusion reactors
  • Bubble columns
  • Suitable for all stirred vessel systems

Identification of

  • Dead zones
  • High shear zones
  • Maximum temperatures
  • Low/high oxygen/substrate/carbon dioxide areas

Lowering

  • Energy demand
  • Cell death rate
  • Operating costs

Test

  • Different stirrer types and positions
  • Feeding positions
  • Sparger configuration and initial bubble size distributions
  • Baffle and heat exchanger configuration

Increasing

  • Holdup
  • Product output
  • Yield, titer

Our Offer 

Consulting

On the basis of the simulation software we offer the following consulting services

– Joint development of a simulation-based solution strategy for your reactor design questions

– Simulation of different predefined geometrical and operational parameter ranges

– Post processing of raw data & reactor performance

– Written report with optimization recommendations

Take advantage of more than ten years of experience in bio-reactor simulation, design and optimization!

Cloud Based Software

Get a cloud-based access to our software, with the following benefits

– Initial training and setup from us

– Simulate your reactors according to your design questions

– Get raw data and automatically post-processed data

– Use the insights to further optimize your reactor

– The lead developers are at your service, should you have any questions

We are also happy to tailor the software guided by your feedback!

Customer Portal

Enable your customers to simulate the bioreactors you are building

– Customized simulation portal only including the reactor types you are selling

– Sell the access to the portal as an add-on with your reactors

– Use the portal as a sales aid for customers with a specific

– Your (potential) customers are able to solve their challenges in silico.

– The portal is equipped with your logo and can be adapted to your cooperate identity rules

Be the first OEM that can offer a simulation solution with your reactors!

Email Us

13 + 8 =

+43 681 207 931 73

​SimVantage
Science Park Graz
Stremayrgasse 16/4
8010 Graz
Austria

office@simvantage.com